Cox® Technic
a discussion place for spinal pain management with Cox® Technic

Blog #9 - Chondroitin Sulfate Shines

December 7, 2016 18:21 by jamesmcoxdcdacbr

A little history...

Discat plus is a Chondroitin Sulfate formula I developed in 1966 following reading the work of Cole, Ghosh and Taylor in a two volume text entitled “THE BIOLOGY OF THE INTERVERTEBRAL DISC”. This two volume text was far ahead of its time. Following studying it, I gained awareness of stopping disc degeneration, prompting disc regeneration, and a beginning of possibly controlling spine pain with chondroitin sulfate administration to people.

The source of Chondroitin Sulfate I used and still use was perna canaliculus, a green lipped mussel from New Zealand and Australia that is harvested from the ocean. It is the most potent source of Chondroitin Sulfate known. (welburn) The intervertebral disc contains a mucopolysaccharide compound know as glycosaminoglycan that absorbs fluid to give the disc its property of turgor (stiffness) within its cells. Loss of glycosaminoglycan accompanies disc degeneration and disc herniation. Glycosaminoglycan is Chondroitin Sulfate. Thus the relationship between administering Chondroitin Sulfate (Discat Plus) along with Cox® Technic for treating disc degeneration and herniation began.

In 1966 I formulated Discat Plus (with Chondroitin Sulfate). This was twenty to thirty years before commercial ventures like health food stores and commercial television learned of it and started to sell it.  Remember it takes 17 years for a new idea or fact to settle into common knowledge. This was true for chondroitin sulfate.

and today... 

Now we are seeing pain relief as well as the anti-inflammatory benefits of Chondroitin Sulfate (as in Discat Plus). Please read the following relief of tactile allodynia in the mouse model when oral chondroitin sulfate was given. 

Source: Nemoto W, Yamada K, Ogata Y, Nakagawasai O, Onodera K, Sakurai H, Tan-No K. Chondroitin sulfate attenuates formalin-induced persistent tactile allodynia. J Pharmacol Sci Aug 5. pii: S1347-8613(16)30091-3. doi: 10.1016/j.jphs.2016.07.009. [Epub ahead of print]

We examined the effect of chondroitin sulfate (CS), a compound used in the treatment of osteoarthritis and joint pain, on the formalin-induced tactile allodynia in mice. A repeated oral administration of CS (300 mg/kg, b.i.d.) significantly ameliorated the formalin-induced tactile allodynia from day 10 after formalin injection. On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS. These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.

CHONDROITIN SULFATE (CS) IS USED IN THE TREATMENT OF OSTEOARTHRITIS AND JOINT PAIN. IT HAS ALSO SHOWN RELIEF OF TACTILE ALLODYNIA IN MOUSE STUDIES. A REPEATED ORAL ADMINISTRATION OF CS (300 MG/KG, B.I.D.) SIGNIFICANTLY AMELIORATED THE FORMALIN-INDUCED TACTILE ALLODYNIA FROM DAY 10 AFTER FORMALIN INJECTION. ON DAY 14, THE PHOSPHORYLATION OF SPINAL P38 MAPK AND SUBSEQUENT INCREASE IN C-FOS-IMMUNOREACTIVE DORSAL LUMBAR NEURONS WERE ATTENUATED BY THE REPEATED ADMINISTRATION OF CS. THESE FINDINGS SUGGEST THAT CS ATTENUATES FORMALIN-INDUCED TACTILE ALLODYNIA THROUGH THE INHIBITION OF P38 MAPK PHOSPHORYLATION AND SUBSEQUENT UP-REGULATION OF C-FOS EXPRESSION IN THE DORSAL LUMBAR SPINAL CORD.

First, what is tactile allodynia? It is pain caused by touch such as clothing against the skin. It is pain caused by so little irritation it would not be considered to cause pain.

Second, what does phosphorylation of spinal p38 mapk and subsequent increase in c-fos-immunoreactive dorsal lumbar neurons mean?

Let's first review. What are MAPK, ERK, P38 pathways? Cellular responses to many external stimuli involve the activation of several types of MAPK (Mitogen-Activated Protein Kinase) signaling pathways. MAPKs are a family of serine/threonine kinases that comprise 3 major subgroups, namely, ERK (Extracellular signal–Regulated Kinase), p38 MAPK and JNK (c-Jun N-terminal Kinases).

An understanding of kinases is basic. Genetic and protein information on pain and disease involves knowing that protein tyrosine kinase is an enzyme that transfers po4 from ATP to protein in the cell. The released po4 attaches to tyrosine to form tyrosine phosphate which then attaches to serine and threonine and this regulates cell division. If irregular, it will set abnormal cell division – cancer.

Pathways to transmit proteins through the cell wall from receptor to DNA, RNA of nucleus of the cell.  MAPK–ERK pathway conducts the protein such as tyrosine kinase attached to serine and threonine through the cell wall into the nucleus of the cell. The p38 pathway routes chemicals through the cell wall into the nucleus of the cell. In this paper, chondroitin sulfate is found to inhibit the p38 pathway to relieve tactile allodynia.

This represents another potential benefit of chondroitin sulfate as an anti-inflammatory pain control.

For further information, I am also sharing the following paper on attenuating the MAPK p38 pathway for neuropathy pain relief (Chen et al). Please know I am not expert in such deep subject cellular pathways, but this is basic knowledge for your consideration. - JMC

Source: Chen NF, Chen WF, Sung CS, Lu CH, Chen CL, Hung HC, Feng CW, Chen CH, Tsui KH , Kuo HM, Wang HD, Wen ZH, Huang SY. Contributions of p38 and ERK to the antinociceptive effects of TGF-β1 in chronic constriction injury-induced neuropathic rats. J Headache Pain. 2016 Dec;17(1):72. Epub 2016 Aug 19.

HERE IS AN EXAMPLE OF SUPPRESSION OF MAPK, ERK, P38 ARE ANTINOCICEPTIVE FOR CHRONIC CONSTRICTION OF A NERVE BY TRANFORMING GROWTH FACTOR-B. TGF-Β1-INDUCED ANALGESIA DURING NEUROPATHY. Transforming growth factor-βs (TGF-βs) are a group of multifunctional proteins that have neuroprotective roles in various experimental models. intrathecal (i.t.) injections of TGF-β1 significantly inhibit neuropathy-induced thermal hyperalgesia, spinal microglia and astrocyte activation, as well as upregulation of tumor necrosis factor-α.  During persistent pain, activation of MAPKs, especially p38 and extracellular signal-regulated kinase (ERK), have crucial roles in the induction and maintenance of pain hypersensitivity. TGF-β1 markedly inhibited phospho-p38 upregulation in neurons, microglial cells, and astrocytes. However, i.t. injection of TGF-β1 also reduced phospho-ERK upregulation in microglial cells and astrocytes.

CONCLUSIONS: The present results demonstrate that suppressing p38 and ERK activity affects TGF-β1-induced analgesia during neuropathy.

Researchers from Australia's RMIT University and SGE International Pty Ltd state that novel omega-3 polyunsaturated fatty acids extracts from the green-lipped mussel (Perna canaliculus) inhibited leukotriene and cyclo-oxygenase (COX) activity, both of which are involved in the inflammatory process. Chronic inflammation has been linked to a range of conditions like heart disease, osteoporosis, cognitive decline and Alzheimer's, and type-2 diabetes. (http://www.nutraingredients-usa.com/Research/Studies-support-green-lipped-mussel-s-anti-inflammatory-properties)

The functions of CHONDROITIN SULFATE PROTEOGLYCANS (CS-PGs) in the central nervous system can be categorized as the regulation of cell adhesion and migration, neurite formation, polarization of neurons, synaptic plasticity, survival of neurons, etc. Chondroitin sulfate (perna canaliculus) is reported to:

  • Repair degraded bone
  • Increase absorption and replacement of calcium
  • Rebuild damaged bone, cartilage, tendon, ligament, and disc
Again, I first formulated Discat Plus in 1966, continued its improvement as research dictated, and continue to use it and make it available to doctors who understand its benefits. Also its use is strengthened by continued research. If interested in this beneficial nutritional addition to the treatment of disc degeneration and spinal stenosis, contact us at www.coxtrc.com and more specifically http://coxtrc.com/supplements/discatplus.html. Thank you!

 

 


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Blog #7 - "Own Your Spine. Own Your Spine Pain."

May 25, 2016 11:30 by jamesmcoxdcdacbr

Why would I tell a patient to "Own your spine. Own your spine pain."? It's the only one he's/she's got! Where is this bluntness coming from? Well, it’s one of those days. A talk with a patient who wants the fix for back pain NOW got my head spinning. I want to share all I know with the patient, assure him that all will be well beyond this pain episode, that if he just embraces his spine for what it can do, all will be well. But pain gets in the way. I get it. Pain turns our rose colored glasses to gray ones in moments like this. Yet reality intervenes with truth, truth that we all must own our own spine as well as its pain on occasion.

This is what I’d like to share with my patient...

So why must we face this reality? Let’s look at it.

For many with spine pain (neck, mid back or low back with or without arm and leg pain or headache), there is no cure for the spinal condition, only control of pain with proper daily living habits. Let’s consider some facts…

Let’s start with genetics. You may be born with a spinal condition that will never by “normal”. Such conditions have big names like spondylolisthesis, transitional vertebra in which one has 4 or 6 lumbar vertebrae instead of 5, scoliosis, fused or incompletely formed vertebrae. These conditions will always be yours to contend with. No one can remake your spine. Like a bruise on an apple that remains on the apple, the spine is still whole even after attempts to remake it, but it remembers what was done.

Same with life experiences the spine goes through. Let’s take aging. Amazingly, the human spine normally begins to degenerate in the second decade of life, in the teen years. Some people have greater disc degeneration than others. However, if one is deconditioned, that is, out of good physical shape, and then does lifting, bending and twisting with such a compromised spine, the scene is set for back pain. Most of us develop some spine pain early in life, and the pain recedes often with no treatment. Then we continue the same lifestyle of eating too much, lifting heavy weight in the wrong posture to lift, etc.,  our spines then continue to degenerate while we do nothing or very little to maintain good health. Then, later in life, we develop more severe spine and extremity pain and think something can be done to allow us to continue this lifestyle without change. Some even think surgery will reverse all their problems only to find it can make them worse.

Let’s next consider injury from falls, lifting heavy weight, car wrecks, etc.

Now if you have a spine that may have developed in a weakened state - the body of a patient deconditioned - and then add injury to it, pain results. Now, if you are such a person and you develop pain in the back or extremities or headaches and go to a doctor expecting some form of care to relieve this pain, hopefully a pill, surgery, exercise, nutritional supplement or spinal manipulation, you want it quickly so you can return to what you were doing and have the pain not return. So many factors play into the equation for injury (even for work injuries - is it alway entirely the job's fault for a work injury?): genetics, lifestyle, physical condition, life choices in deciding how to use the body to avoid injury or pain may come into play.

DO YOU SEE THE FOLLY OF THIS ATTITUDE?  There is no cure for many spine problems, only control through maintaining a healthy body, learning what you can and cannot do, exercise, visiting the chiropractor for spinal alignment, spinal decompression, spinal manipulation, and conditioning, and supplementing with nutrition to develop and maintain healthy discs in the spine.  A person with a weak spine cannot expect to nevertheless do anything with that spine that he or she wants without a pain consequence forever.  That is like asking a diabetic person to eat a box of chocolates and not be adversely harmed.

OWN IT.  There is no way for you to make a race horse out of a pony. Be content with what you have, and make it work. Appreciate your spine as it is. You may not like these facts, but can you change them? No. Own your spine, and allow it to perform at its peak performance for you and your lifestyle. That requires honest realization of your limitations and living with them while being in the best physical health you can attain. YOU ARE THE ONE WITH THE MOST TO GAIN. The chiropractor is your back pain specialist, your treating doctor, coach, cheerleader, and guide. Work with the trained and even certified in Cox Technic chiropractic physician who uses flexion distraction to maximize your spine’s usefulness and ability!

Respectfully submitted, James M. Cox, DC, DACBR, FICC, HonDLitt, FACO(H)


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Blog #6 - What Is Cox® Flexion Distraction Decompression Spinal Manipulation?

March 9, 2016 06:16 by jamesmcoxdcdacbr

Cox Technic Flexion Distraction Decompression Spinal Manipulation is evidence-based spinal care, a form of spinal manipulation in which the human spine is placed in distraction (a type of measured controlled traction of the spine) delivered on a specialized spinal manipulation instrument. The Cox Table is the well-designed instrument of choice.

Five specific changes in spine mechanics occur in the intervertebral disc and nerve openings with this procedure (1):

  1. The height of the intervertebral disc is increased.
  2. The size of the nerve opening which is called the intervertebral foramen is increased up to 28% in area.
  3. The pressure within the intervertebral disc which is created by the fluid within the disc is reduced from a positive pressure to a negative pressure gradient. This aids in dropping the pressure on the pain sensitive nerves within the disc and the pressure on the nerve which lies behind the disc which causes sciatic or leg pain when compressed over 20 mm of mercury pressure.
  4. The movements of the spine are restored. A specific spinal vertebral level (consisting of the intervertebral disc and the moveable joints lying behind the disc) is placing into its normal physiological ranges of motion. Remember that loss of spinal mobility is a part of back pain whether it be acute or chronic. Restoring normal spinal mobility offers improved activities of daily living and diminishing spinal stress that causes back pain.
  5. Nervous system tracts of nerves from the spine to the human brain are stimulated when spinal manipulation is administered. These nerve tracts respond to touch, motion, temperature, and pressure to initiate nerve reflexes that relieve pain and allow for normal spinal motion. Such nerve tracts can also affect balance and equilibrium that are so often affected with spinal pain.

The goal of Cox® distraction spinal manipulation is summarized as follows: Attain and maintain physiological range of spine motion with the greatest relief of pain. It is also vital to note that some spinal conditions are not cured, that is to say all the pain is relieved and the person can do any activity without pain recurrence. NO, some spinal conditions that are congenital (born with) or acquired from injury or degenerative spine changes are controlled not cured. In such cases it is important that the patient follow the training given by the chiropractor concerning proper ergonomics (how to move, bend, lift, twist the spine) to avoid pain, perform the specific exercise program developed for your spine condition, and in many cases have dedicated times for undergoing Cox® distraction spinal manipulation so as to maintain relief. Cox Flexion Distraction may well be a beneficial alternative to back surgery for back pain patients.

Respectively submitted,

James M. Cox, DC, DACBR

 


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Spinal Manipulation Use Grows as Its Benefits are Experienced

March 9, 2016 02:38 by jamesmcoxdcdacbr

Tremendous growth in the use of spinal manipulation to treat human spine pain conditions is reported in the literature today. Chiropractic, osteopathy, physical therapy, and allopathy all research and document these benefits; let’s look at some of these benefits.

Physical therapists find tension type headache patients were relieved by suboccipital inhibitory pressure and suboccipital spinal manipulation (upper neck and base of the skull area) in a combined use. It is effective at changing different dimensions of quality of life, and the results support the effectiveness of treatments applied to the suboccipital region for patients with tension type headache. (1)

Treatment of 455 low back pain patients with osteopathic manipulation treatment showed substantial improvement which was defined as 50% or greater reduction of pain at week 12 compared with baseline. Patients with higher pain levels actually showed the greatest relief. In another study, 6 osteopathic spinal manipulation treatments over an 8 week period gave significant and clinically relevant recovery of chronic low back pain. Interestingly, patients without depression were more likely to recover from chronic low back pain with osteopathic manipulation therapy.  A trial of osteopathic manipulation may be useful before progressing to other more costly or invasive interventions in the medical management of patients with chronic low back pain. (2)

Patient age can determine the best form of spinal manipulation to be administered. The American Academy of Osteopathy studied the use of osteopathic spinal manipulative treatment (OMT) in 3 age groups of patients: <65 years, 65-79 years, and ≥80 years.  Osteopathic spinal manipulative treatment can be used to address serious conditions affecting older persons (≥65 years). Spinal manipulation was  used equally in all 3 age groups but varied in the type of spinal manipulation given. Over age 65, more gentle spinal manipulation procedures are used while more vigorous types of spinal manipulation can be delivered in patients under age 65. Respiratory and neurologic conditions were often treated with spinal manipulation. (3)

Chiropractic spinal manipulation showed 86% of low back pain patients showed relief following 12 spinal manipulation treatments given over an average of 29 days. The type of spinal manipulation used was Cox® flexion distraction decompression. (4)

Spinal manipulation is first line treatment for low back pain. (5) When considering treatment for low back pain and sciatic pain, note that epidural steroid injections are reported no better than a placebo for sciatica and spinal stenosis.  These facts can aid a patient in choosing their treatment for headache or low back pain with or without leg pain.

Respectfully,

James M. Cox, DC, DACBR

 


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