Kaneuchi Y, Sekiguchi M, Kameda T, Kobayashi Y, Konno S. Temporal and Spatial
Changes of μ-Opioid Receptors in the Brain, Spinal Cord and Dorsal Root
Ganglion in a Rat Lumbar Disc Herniation Model. Spine 2019;44(2):85-95
In a rat model, placing nuclear material on the dorsal root
ganglion showed that 7 and 14 days later the spinal cord and DRG, μ-opioid
receptor (MOR) expression was significantly lower than controls, and at day 21
the nucleus accumbens was significantly decreased compared to the sham group.
Changes of opioid expression in the nucleus accumbens, spinal cord and DRG were
associated with pain-related behavior. This result might show the underlying
pathogenesis of the resistance to opioid agonists in the patient with lumbar
disc herniation.
Dr. Cox finds this an awesome finding!
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